Liverpool Football Club of England will face rivals Manchester United FC in the Europa League last 16, while Tottenham Hotspurs have been drawn against Bundesliga giants Borussia Dortmund.
The draw was held on Friday in Nyon, Switzerland.
The News Agency of Nigeria (NAN) reports that the games will be played on Thursday, March 10 and March 17.
Valencia, managed by former England defender, Gary Neville, face fellow Spanish side Athletic Bilbao, while Sevilla – winners of the last two Europa League titles – play Basel of Switzerland.
NAN reports that the Swiss side’s St Jakob-Park ground will host the final match of the competition, with the winners qualifying for next season’s Champions League.
Speaking on the match-up, Liverpool manager Jurgen Klopp said: “You can ask my staff about when they asked me yesterday and who I wanted. I said ‘Man United’”.
“I think we have to clear something. We had a good game when we lost 1-0 (in the Premier League in January), but it was not what we deserved.
“It gives us a chance to make it better and that is what we will try to do,” he said.
United, who have never won the tournament, beat FC Midtjylland 6-3 on aggregate with Marcus Rashford scoring twice on his debut as United won the second leg 5-1 on Thursday.
Liverpool beat German side Augsburg 1-0 on aggregate with James Milner scoring the only goal of the tie on Thursday.
The Reds won the old UEFA Cup, which turned into Europa League, three times, in 1973, 1976 and 2001.
It will be the first time United and Liverpool will face each other in European competition.
The last all-English match in the UEFA Cup or Europa League was Liverpool versus Tottenham in April 1973.
Spurs, who beat Fiorentina 3-0 on Thursday to seal their tie 4-1 on aggregate, won the 1972 and 1984 UEFA Cups.
Sevilla – who have won the tournament a record four times – are bidding to become the first side to win it three years in a row.
The full Europa League round of 16 draw:
Shakhtar Donetsk vs Anderlecht
Basel vs Sevilla
Villarreal vs Bayer Leverkusen
Athletic Bilbao vs Valencia
Liverpool vs Manchester United
Sparta Prague vs Lazio
Borussia Dortmund vs Tottenham
Fenerbahce vs Braga